Synthetic ribosomes
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چکیده
منابع مشابه
Synthetic ribosomes
1 describes the design, synthesis and operation of an artificial small-molecule capable of synthesizing peptides in a sequence-specific manner. The design of this artificial molecular machine was, in the author's own words, " inspired by the ribosome " ; 2 with several elements analogous to ribosomal protein synthesis (Fig. 1). The tRNA's of conventional translation are substituted by amino aci...
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Isolated silkgland ribosomes were irradiated with X-rays, and their activities to synthesize fibroin in vitro were examined. A marked decrease in their activities was observed when ribosomes were incubated at 37•Ž following X-irradiation. Per cent decrease in the ribosomal activity leveled off at 37•Ž after 30 minutes incubation . The extent of decrease was dependent on X-ray dose. Treatment of...
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The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates in ribosome synthesis (Harnpicharnchai et al., 2001; Bassler et al., 2001).
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RNA polymerase doesn't make deliveries R esearchers are divided over whether RNA polymerase tracks down genes that are ready to be transcribed or whether the enzyme remains in place. Xu and Cook add to the evidence that a gene has to relocate to one of a few sites in the nucleus to be transcribed. One possibility is that the RNA polymerase, the DNA-reading enzyme, moves from gene to gene, trans...
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Several pathogenic bacteria, including Shigelladysenteriae and certain strains of Escherichia coli, produce potent class 2 ribosome inhibiting proteins (RIPs) termed Shiga toxins (Stx). The toxins are bipartite molecules composed of a single A chain (StxA) noncovalently associated with a pentamer of receptor-binding B subunits (StxB). StxA and Stx1A from E. coli are protoxins. Proteolysis gener...
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ژورنال
عنوان ژورنال: Bioengineered
سال: 2013
ISSN: 2165-5979,2165-5987
DOI: 10.4161/bioe.23640